FEW DAYS OFF
ΜΕΡΙΚΕΣ ΜΕΡΕΣ ΞΕΚΟΥΡΑΣΗ
PLECAT PENTRU CATEVA ZILE
(Brexians lair)
29/11/06
(Brexians lair)
28/11/06
ΓΙΑ ΤΟΥΣ ΚΥΝΗΓΟΥΣ......
(Brexians lair)
23/11/06
We're only human? It's more complex than that
Wed Nov 22, 1:07 PM ET
PARIS (AFP)
New investigations into the code for life suggest the assumption that humans are genetically almost identical is wide of the mark, and the implications could be resounding.
Current thinking, inspired by the results five years ago from the Human Genome Project, is that the six billion humans alive today are 99.9 percent similar when it comes to genetic content and identity.
But major research work, published on Thursday, suggests we are genetically more diverse -- and the repercussions could be far-reaching for medical diagnosis, new drugs and the tale of human evolution itself.
Until now, analysis of the genome has focussed overwhelmingly on comparing flaws, or polymorphisms, in single "letters" in the chemical code for making and sustaining human life.
An international consortium of scientists has taken a different tack and believe they have uncovered a complex, higher-order variation in the code.
This better explains why some individuals are vulnerable to certain diseases and respond well to specific drugs, while counterparts swiftly fall sick or never respond to treatment, the authors believe.
Their focus has been to dig out deletions or duplications of code among relatively long sequences of individual DNA and then compare these so-called copy number variations (CNVs) across a range of volunteers of different ancestry.
The researchers were astonished to locate 1,447 CNVs in nearly 2,900 genes, or around one eighth of the human genetic code.
"Each one of us has a unique pattern of gains and losses of complete sections of DNA," said Matthew Hurles of Britain's Wellcome Trust Sanger Institute, one of the project's partners.
"One of the real surprises of these results was just how much of our DNA varies in copy number. We estimate this to be at least 12 percent of the genome."
"The copy number variation that researchers had seen before was simply the tip of the iceberg, while the bulk lay submerged, undetected. We now appreciate the immense contribution of this phenomenon to genetic differences between individuals."
Some of the missing or duplicated stretches are very long, suggesting that, like backroom switches in a protein factory, CNVs must have a big impact on gene expression.
Nearly 16 percent of genes that are known to be related to disease have CNVs, the group found.
These include genes involved in rare genetic disorders such as DiGeorge, Williams-Beuren and Prader-Willi syndromes and those linked with schizophrenia, cataracts, spinal muscular atrophy and atherosclerosis.
But kidney disease, Parkinson's, Alzheimer's and vulnerability to malaria and the human immunodeficiency virus (HIV), which recent research has blamed on single-letter variations in the gene code, may also well be rooted in CNVs, the doctors believe.
"The stage is set for global studies to explore anew... the clinical significance of human variation," said Huntington Willard and Kevin Shianna of the Institute for Genome and Science Policy at Duke University in North Carolina, in a review of the research.
Evolution is another area that will come under new scrutiny.
The "Out of Africa" scenario, by which Homo sapiens emerged from east Africa and spread around the globe, will not be challenged, though.
Our origins are so recent that the vast majority of CNVs, around 89 percent, was found to be shared among the 269 people who volunteered blood as samples for the study.
These individuals included Japanese from Tokyo, Han Chinese from Beijing, Yoruba from Nigeria and Americans of Northern and Western European ancestry.
All the same, there are widespread differences in CNVs according to the three geographical origins of the samples.
This implies that, over the last 200,000 years or so, subtle variants have arisen in the genome to allow different populations of humans adapt to their different environments, Wellcome Trust Sanger said in a press release.
The research, which appears in the British journal Nature, is based on two technical breakthroughs, one in faster, accurate sequencing of DNA and the other in a powerful software programme to spot the CNVs.
(Brexians lair)
21/11/06
18/11/06
CE BRUIT DE LA MER
ΝΤΕΝΙΖ ΛΕΒΕΡΤΟΒ
1923
À la manière de Jules Supervielle
Αυτό τον ήχο, πάντοτε γύρω μας, της θάλασσας,
το δέντρο ανάμεσα στους πλοκάμους του πάντα τον άκουγε,
και το άλογο βουτά το μαύρο σώμα του στον ήχο
τεντώνοντας το λαιμό σαν να ‘θελε να πιει νερό,
σα να λαχταρούσε ν’ αφήσει τους αμμόλοφους και να γίνει
ένα μυθικό άλογο στην πιο μακρινή απόσταση,
αδελφωμένο με το κοπάδι των αφροπροβάτων
-το δέρας είναι μόνο γα την όραση-
να γίνει στ’ αλήθεια ο γιος αυτών των αλμυρών νερών
και να βοσκάει φύκια στα βαθιά λιβάδια.
Αλλά πρέπει να μάθει να περιμένει, να περιμένει στην ακτή,
τάζοντας τον εαυτό του στα κύματα του πελάγου
-ναι κάποια μέρα-
ελπίζοντας στον βέβαιο θάνατο, χαμηλώνοντας
πάλι το κεφάλι προς το χορτάρι.
(Brexians lair)
ΡΟΜΠΕΡΤ ΛΟΟΥΕΛ
1917-1977
ΕΠΙΓΡΑΜΜΑ
Σκέψου τον Λεωνίδα και τους οπλίτες ίσως
να λάμπουν λευτεριά
χτενίζοντας ο ένας του άλλου τα χρυσά Μποτιτσέλεια
μαλλιά στις Θερμοπύλες – φίλοι η εραστές,
νύφη και γαμπρός –
κινήθκαν προς τη θέση θάνατος.
(Brexians lair)
ΟΙ ΛΕΞΕΙΣ ΤΟΥ ΤΕΛΟΥΣ
ΛΟΥΙ ΑΡΑΓΚΟΝ
1897-1982
[....]
πέταξαν όλα τα πουλιά μέσα από τα κλαριά μου
οι άδειες φωλιές ξεραίνονται καθώς το δάκρυ
άκρη άκρη εκεί στο μάγουλο
έφυγε κι ο ζωγράφος τούτου εδώ του πίνακα που κατοικώ
έτσι καθώς η αράχνη
έτσι καθώς μια μεταμέλεια
Τι ζωγραφίζει τι να ζωγραφίζει Ίσως τη νεότητα
Και τις ευτυχισμένες χώρες τους ανθρώπους που
Φοβάμαι τόσο οι μέρες τους στις μέρες μου μη μοιάσουνε μια μέρα
Τι ζωγραφίζει εκείνος που στα πράγματα τα χρώματά τους τα καινούργια δίνει
Ίσως εσάς παιδιά ωραία παιδιά καθώς κι εμείς ση δυστυχία ταγμένα
Που αφήνετε μέσα από τα δάχτυλά σας να κυλά ο καιρός ης ηδονής
Πεισματικά πιστά στο ρόλο των προσώπων σας τον άψογο
Πώς χάνονται όλα μέσα μου όλα σβήνουν
Εκτός απ’ τη σκληρή ηδονή μετά πολύ
Που έχει φύγει
(Brexians lair)
Η ΑΓΑΠΗΜΕΝΗ
ΠΩΛ ΕΛΥΑΡ
1895-1952
Στέκεται ορθή στα βλέφαρά μου
Και τα μαλλιά της μπλέκονται μες στα δικά μου
Έχει το σχήμα των χεριών μου
Έχει το χρώμα των ματιών μου
Βυθίζεται μες στη σκιά μου
Σα μια πέτρα στον ουρανό
Έχει τα μάτια της πάντ’ ανοιχτά
Και δε μ’ αφήνει σ’ ύπνο να γείρω
Τα όνειρά της μέσα στο φως
Σβήνουν τον ήλιο
Με κάνουν να γελώ, να κλαίω και να γελώ
Και να μιλώ χωρίς να έχω τίποτα να πω.
1895-1952
Στέκεται ορθή στα βλέφαρά μου
Και τα μαλλιά της μπλέκονται μες στα δικά μου
Έχει το σχήμα των χεριών μου
Έχει το χρώμα των ματιών μου
Βυθίζεται μες στη σκιά μου
Σα μια πέτρα στον ουρανό
Έχει τα μάτια της πάντ’ ανοιχτά
Και δε μ’ αφήνει σ’ ύπνο να γείρω
Τα όνειρά της μέσα στο φως
Σβήνουν τον ήλιο
Με κάνουν να γελώ, να κλαίω και να γελώ
Και να μιλώ χωρίς να έχω τίποτα να πω.
(Brexians lair)
SUNDAY BLOODY SUNDAY-U2
I can't believe the news today
I can't close my eyes and make it go away.
How long, how long must we sing this song?
How long, how long?
'Cos tonight
We can be as one, tonight.
Broken bottles under children's feet
Bodies strewn across the dead-end street.
But I won't heed the battle call
It puts my back up, puts my back up against the wall.
Sunday, bloody Sunday.
Sunday, bloody Sunday.
Sunday, bloody Sunday.
Sunday, bloody Sunday.
Oh, let's go.
And the battle's just begun
There's many lost, but tell me who has won?
The trenches dug within our hearts
And mothers, children, brothers, sisters
Torn apart.
Sunday, bloody Sunday.
Sunday, bloody Sunday.
How long, how long must we sing this song?
How long, how long?
'Cos tonight
We can be as one, tonight.
Sunday, bloody Sunday.
Sunday, bloody Sunday.
Wipe the tears from your eyes
Wipe your tears away.
I'll wipe your tears away.
I'll wipe your tears away.
I'll wipe your bloodshot eyes.
Sunday, bloody Sunday.
Sunday, bloody Sunday.
And it's true we are immune
When fact is fiction and TV reality.
And today the millions cry
We eat and drink while tomorrow they die.
The real battle just begun
To claim the victory Jesus won
On...
Sunday, bloody Sunday
Sunday, bloody Sunday..
(Brexians lair)
17/11/06
River Jordan
I'm goin' down to the river Jordan
I'm goin' down to the river Jordan
I'm goin' down to the river Jordan
I'm goin' down to the river Jordan
One of these days.
I'm gonna sit at the welcome table
I'm gonna sit at the welcome table
I'm gonna sit at the welcome table
Gonna sit at the welcome table
One of these days.
I'm gonna find that blessed salvation
I'm gonna find that blessed salvation
I'm gonna find that blessed salvation
Gonna find that blessed salvation
One of these days.
I'm gonna walk and talk with Jesus
I'm gonna walk and talk with Jesus
I'm gonna walk and talk with Jesus
Gonna walk and talk with Jesus
One of these days.
I'm gonna hold hands with my Master
I'm gonna hold hands with my Master
I'm gonna hold hands with my Master
I'm gonna hold hands with my Master
One of these days.
Now I'm goin' down to the river Jordan
I'm goin' down to the river Jordan
I'm goin' down to the river Jordan
Goin' down to the river Jordan
One of these days.
Janis Joplin
(Brexians lair)
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